【Background】： Previous studies have demonstrated that early intervention was the best plan to inhibit the progression of Alzheimer’s disease (AD), which relied on the discovery of early diagnostic bi...

【Highlights】： ?P-tau217 correlates with brain atrophy and cognitive impairment in AD patients ?Antibody against p-tau217 attenuates pathology and neuronal loss in tauopathic mice ?P-tau217 antibody...

【PUBLIC SUMMARY】: - In-depth proteomics workflow for profiling paired cerebrospinal fluid (CSF) and serum proteomes. - Independent multicenter set combined with multiple methods for...

【Background】Mutations in colony-stimulating factor 1 receptor (CSF1R) are known to cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), which has been recen...

【Background】: Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) were two major motor neuron diseases with similar symptoms and poor outcomes. This study aimed to ident...

【Abstract】 Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s and cardi...